Chemokine-Guided Angiogenesis Directs Coronary Vasculature Formation in Zebrafish

Harrison et al., 2015, Developmental Cell 33, 442–454

Harrison et al. describe coronary vessel formation in juvenile zebrafish by endocardial cells that migrate onto the ventricle. These endothelial cells sprout to create the vascular network under the guidance of chemokine signaling. Without these signals, the coronary vessels fail to form, resulting in reduced regenerative potential in adult zebrafish.